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KMID : 1137020120230020098
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Journal of Gynecologic Oncology
2012 Volume.23 No. 2 p.98 ~ p.102
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Cut-off value of D-dimer for prediction of deep venous thrombosis before treatment in ovarian cancer
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Kawaguchi Ryuji
Furukawa Naoto
Kobayashi Hiroshi
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Abstract
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Objective: The purpose of the present study was to elucidate the incidence of deep venous thrombosis (DVT) before treatment in ovarian cancer and the appropriate cut-off value of D-dimer (DD) for the diagnosis of DVT.
Methods: Between July 2007 and October 2008, eighty seven patients with presumed ovarian cancer (final diagnosis: ovarian cancer, n=59; borderline malignancy, n=28) were enrolled. Measurement of DD levels and subsequent venous ultrasonography were performed before treatment.
Results: The mean DD level was 4.1 μg/mL. Subsequent venous ultrasonography revealed DVT in 14 of 87 (16.1%) patients (ovarian cancer, 12 cases; borderline malignancy, 2 cases). None were found to have developed DVT if they had a DD level of <1.5 μg/mL. If 1.5 μg/mL was used as a cut-off value for DD levels to diagnose DVT, sensitivity, specificity, positive predictive value, and negative predictive value were 100%, 61.6%, 33.3%, and 100%. There was noclinical onset of postoperative pulmonary thromboembolism.
Conclusion: Our data suggest that presumed ovarian cancer patients with at least more than 1.5 μg/mL should be examined using venous ultrasonogaphy to detect DVT.
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KEYWORD
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D-dimer, Ovarian neoplasms, Venous thrombosis
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